Tetracycline

     These are broad spectrum bacteriostatic short action antibacterial. It is partially absorbed from GIT and excreted mainly Unchanged in Urine and should be avoided in renal disease.

Mechanism of action:

        Tetracycline is the protein synthesis inhibitor. It binds to the 30s subunit of the bacterial ribosomes as a result of which blocks the binding of amino acyl-tRNA to the receptor site on mRNA- ribosome

Complex.

        It prevents making the amino acid for the growing peptide chain and because of not binding to ribosomes permanently, it is an bacteriostatic anti-biotic.

Indication:

Ø Veneral disease (syphilis)

Ø Mycoplasma

Ø Rickettsia

Ø Lyme disease, relapsing fever

Ø Chlamydial infections

Ø Respiratory tract infection

Ø Atypical pneumonia due to Mycoplasma pneumonia

Ø Urinary tract infection

Ø Lymphogranuloma venereum

Ø Aphthous ulcer

Ø Brucellosis

Ø Anthrax

Ø Pelvic inflammatory disease (PID)

Ø Plague

Ø Bacterial diarrhea

Ø Prevention of exacerbations of chronic bronchitis

Preparation:

        It is available in the forms of capsule, injection & ointment such as:

        Tetracycline Capsule 250mg and 500mg

        Tetracycline 250mg vial for I.V. inj.

        Oxytetracycline capsule 250mg and 500mg

        Doxycycline capsule and 100mg